RESUMEN
The outbreak of COVID-19 forced Chinese Football Association to adopt a special format for the 2020 Chinese Football Super League (CSL) after 5-month suspension. All 160 matches (decreased from 240) were divided into two stages (round robin;two-legged knockout) and played behind closed doors in two neutral cities (Suzhou and Dalian). The purpose of this study was to investigate the influence of absence of spectators and format change on teams' winning percentage and match performance. Technical-tactical and event data of all 400 matches during 2019 and 2020 seasons played by 18 teams were collected. A total of 26 performance indicators were extracted and standardized from the original data. The independent t-test results showed that there were statistically significant differences in 13 performance indicators between 2019 season home win and 2020 season win: shot, shot not on target, simple pass, pass, pass accurate, key pass, corner, corner accurate, dribble and take on (p<0.025, absolute ES: 0.28-0.74) for player performance as well as defensive fouls, defensive third foul and yellow cards for referee decision-making (p=0.001, absolute ES: 0.42-0.45). And there were statistically significant differences in 16 performance indicators between 2019 season home not win and 2020 season not win: shot, shot not on target, touch, simple pass, pass, pass accurate, key pass, corner, corner accurate, dribble, defensive duel, penalty shot and clearance for player performance (p<0.04, absolute ES: 0.21-0.93) as well as defensive third foul, defensive foul and yellow card for referee decision-making (p<0.015, absolute ES: 0.29-0.43). The findings implied that the change of match locations and absence of team supporters led to a decrease in teams' match performance and an increase in referees' decision. Although top-ranked teams seemed to be unaffected and the low-ranked teams showed an increase in winning percentage, the fairness of such tournament format needs to be reconsidered.
RESUMEN
OBJECTIVE: Because of the limited treatment options available, oral lopinavir/ritonavir (LPR) was used for treating coronavirus disease (COVID-19) in pediatric patients. This study aimed to assess the efficacy and safety of LPR in COVID-19 pediatric patients with mild symptoms. PATIENTS AND METHODS: This retrospective multicenter analysis included hospitalized children with mild COVID-19 who received LPR at one of 13 hospitals in China from January 1, 2020, to June 1, 2020. Patients treated with LPR were matched with patients not treated with LPR (1:4) according to age, sex, and length of symptom onset and hospitalization. Descriptive statistics and non-parametric tests were applied to compare differences between groups. Kaplan-Meier probability curves and Cox regression models were used to analyze nasal swab turning negative time (recovery time) and hospital discharge days. RESULTS: In total, 23 patients treated with LPR were matched with 92 untreated controls. The median age of patients was 6 years, and 56.52% of them were male. All patients were discharged from the hospital after being cured. The treatment group had a longer nasal swab turning negative time (hazard ratio [HR] 5.33; 95% CI: 1.94-14.67; p = 0.001) than the control group. LPR treatment was also associated with a longer hospitalization time (HR 2.01; 95% CI: 1.24-3.29; p = 0.005). After adjusting for the influence of LPR treatment, adverse drug reaction events were associated with a longer nasopharyngeal swab negative time (HR 4.67; 95% CI 1.35-16.11; p = 0.015). CONCLUSIONS: For children with mild COVID-19, LPR is inferior to conventional treatment in reducing virus shedding time and hospitalization duration and is associated with increased adverse reactions.